The Department of Laboratory Medicine and Pathology at the University of Minnesota Medical School is committed to bringing leading-edge basic and applied research and innovation to patient care.
The research-intensive faculty within the department have several major focus areas including cancer, immunology, cardiovascular disease, renal disease, diabetes, and genetics. The faculty consist of tenured associate and full professors, several of which currently hold endowed chairs or professorships. They interface with University of Minnesota departments and centers such as the Center for Immunology, Masonic Cancer Center, and the Institute for Translational Neuroscience.
Downtown Minneapolis viewed from a basic research laboratory
Brenner tumor (IHC for E-cadherin)
Polychromatic crystalline keratopathy of the cornea
Pap smear with endocervical adenocarcinoma in situ
Macrophages (in red) surrounding a growing ductal structure in the mammary gland
Lymph node with a micrometastasis from ductal carcinoma of the breast
Leydig cells (Reinke crystal)
Department of Laboratory Medicine and Pathology Division of Anatomic Pathology
Hematopathologist Mike Linden is visiting professor in Arequipa, Peru
Karger collaborates on kids' lab testing and health report
Amy Karger recently collaborated with members of the American Association for Clinical Chemistry's Pediatric and Maternal-Fetal Division on an AACC policy report entitled "Advancing Children's Health through Pediatric Laboratory Medicine." "While clinical providers are well versed in understanding the adage that 'children are not small adults,' the pediatric laboratory medicine community recognizes that the unique clinical lab testing needs of children are at times neglected," Karger says. The goal of Karger and her colleagues is to bring attention to the unique laboratory testing needs of infants and children such as newborn screening, a highly successful public health program that identifies newborns with severe but treatable disorders. It is critical to develop robust pediatric reference intervals for laboratory tests to ensure accurate diagnosis and treatment of children with diseases and conditions that typically affect them.
Pediatric laboratory professionals play an important role in today's rapidly changing healthcare delivery system by providing high quality laboratory results and tests that are tailored to meet the unique needs of children, Karger says. (firstname.lastname@example.org)
Online pathology course
LAMP 4177 (3 credits, Spring/Summer)
The Nature of Disease: Pathology for Allied Health Students
The course is a study of the mechanisms of human disease. Students receive a substantial foundation in the pathobiology of human disease and medical terminology. The course covers general pathology followed by organ system pathology.
LAMP 4177 is a good foundation course for a degree in the Health Sciences including:
- Medical Laboratory Science
- Health & Wellness ICP
Dehm-led team finds genomic defects in treatment-resistant prostate cancer
Scott Dehm and his colleagues have identified genomic structural rearrangements in the androgen receptor (AR-GSRs) that may serve to limit current treatment options for prostate cancer patients. In a paper published in Nature Communications, they report that AR-GSRs in prostate cancer metastatic tissues enable cancer cells to circumvent current androgen receptor-targeted treatments. They conclude that their study "advances understanding of the prostate cancer genome by identifying the frequency, spectrum and functional impact of widespread AR-GSR events in clinical prostate cancer tissues." The study provides key insight into the development of disease resistance and suggests promising avenues for the development of more effective therapies.
Dehm partnered with Christine Henzler and Rendong Yangof the Minnesota Supercomputing Institute, faculty in the Masonic Cancer Center and the Department of Computer Science and Engineering, and faculty at the University of Washington and University of Texas Southwestern Medical Center.