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  Home > About Lab Medicine & Pathology > Faculty and Staff > Danni Li, Ph.D.

Danni Li, Ph.D.

Contact Information

Phone: 612-626-0299
Fax: 612-625-1121




Laboratory Medicine & Pathology
Mayo Memorial Building, D250-1 (MMC 609)
420 Delaware St., S.E.
Minneapolis, MN  55455

Assistant Professor
Director of Clinical Chemistry

Research Interests

  • Carbohydrate modified proteins as clinical diagnostics
  • Cancer biomarkers
  • Proteomics
  • Assay Development

Educational Background

  • Zhejiang University, Hangzhou, China (2002), B.S. (Chemistry)
  • University of Minnesota, Minneapolis, MN (2007), Ph.D. (Analytical Chemistry)
  • Johns Hopkins University, Baltimore, MD (2009), Fellowship (Clinical Chemistry)

Professional Background

  • Jan 2010- Sep 2011: Instructor, Department of Pathology, Johns Hopkins University, Baltimore, MD
  • Sep 2011-Aug 2012: Assistant Professor, Department of Pathology, Johns Hopkins University, Baltimore, MD
  • Sep 2012-present: Assistant Professor, University of Minnesota, Minneapolis, MN 

Board Certification

  • American Board of Clinical Chemistry


Peer-Reviewed Research Articles

  • Meany DL, Poe BG, Navratil M, Moraes CT, and Arriaga EA: Superoxide released into the mitochondrial matrix. Free Radial Biology and Medicine, 2006, 41(6): 950-959
  • Meany DL, Xie H, Thompson LV, Arriaga EA, and Griffin TJ: Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry. Proteomics, 2007, 7(7): 1150-1163
  • Meany DL, Thompson L, and Arriaga EA: Simultaneously monitoring the superoxide in the mitochondrial matrix and extramitochondrial space by micellar electrokinetic chromatography with laser-induced fluorescence. Analytical Chemistry, 2007, 79(12): 4588-4594
  • Meany D, Schowinsky J, and Clarke W: Effects of hemolysis and lipemia on the COBAS® salicylate and acetaminophen assays compared to GDS assays. Clinical Biochemistry, 2008, 41(18):1486-1488
  • Feng J, Xie H, Meany DL, Thompson LV, Arriaga EA, and Griffin TJ: Quantitative proteomic profiling of muscle type-dependent and age-dependent protein carbonylation in rat skeletal muscle mitochondria. Journal of Gerontology A: Biological Sciences and Medical Sciences, 2008, 63(11):1137-1152
  • Meany DL, Zhang Z, Sokoll LJ, Zhang H, and Chan DW: Glycoproteomics for prostate cancer detection: change in serum PSA glycosylation patterns. Journal of Proteome Research, 2009, 8(2):613-619
  • Tian Y, Gurley K, Meany DL, Kemp CJ, and Zhang H: N-linked glycoproteomic analysis of formalin-fixed and paraffin-embedded tissues. Journal of Proteome Research, 2009, 8(4):1657-1662
  • Li Y, Sokoll LJ, Rush J, Meany D, Zou N, Chan DW, and Zhang H: Targeted detection of prostate cancer proteins in serum using heavy-isotope-labeled-peptide standards and MALDI-TOF/TOF. Proteomics Clinical Applications, 2009, 3(5), 597–608
  • Meany DL and Clarke W: Opiate DAU screening using dried urine specimens. Clin Chim Acta, 2009, 401 (1-2): 188-189
  • Harlan R, Clarke W, Di Bussolo JM, Kozak M, Straseski J, and Meany DL: An automated turbulent flow liquid chromatography-isotope dilution mass spectrometry (LD-IDMS) method for quantitation of serum creatinine. Clin Chim Acta, 2010, 411(21-22), 1728-1734
  • Meany DL, Hackler L Jr, Zhang H, and Chan DW: Tyramide signal amplification for antibody-overlay lectin microarray: a strategy to improve the sensitivity of targeted glycan profiling. Journal of Proteome Research, 2011, 10(3), 1425-1431
  • Li D, Chiu H, Gupta V, Chan DW, Validation of a multiplex immunoassay for serum angiogenic factors as biomarkers for aggressive prostate cancer. Clin Chim Acta, 2012, 413(19-20), 1506-11
  • Li D, Chiu H, Chen J, Zhang H, and Chan DW: Integrated Analyses of Proteins and Their Glycans in a Magnetic Beads Based Multiplex Assay Format. Clin Chem, 2012, Accepted.

Review Articles

  • Meany DL, Sokoll LJ, and Chan DW: Early Detection of Cancer: Immunoassays for Plasma Tumor Markers. Expert Opinion on Medical Diagnostics, 2009, 3(6): 597-605
  • Meany DL and Chan DW: Aberrant glycosylation associated with enzymes as cancer biomarkers. Clinical Proteomics, 2011, 8(1), 7-20


  • Meany DL, and Chan DW: Comparability of tumor marker immunoassays: still an important issue for clinical diagnostics? Clinical Chemistry and Laboratory Medicine, 2008, 46(5): 575-576

Case Reports

  • Meany DL and Clarke W: A case study of methanol: should laboratories also test formate? Therapeutics and Toxins News, Fall 2007: 4-5
  • Meany DL, Jan de Beur SM, Bill MJ, and Sokoll LJ: A case of renal osteodystrophy with unexpected serum intact parathyroid hormone concentrations. Clinical Chemistry, 2009, 55(9):1737-1739

Book Chapters

  • Devaraj S, Meany DL, Sokoll LJ, and Jialal I: Laboratory assessment of metabolic syndrome and obesity. In: Winter WE, Sokoll LJ, and Jialal I, eds. Handbook of diagnostic endocrinology, 2nd ed. Washington D.C.: AACC Press, 2008.
  • Meany DL and Clarke W: Gentamicin and other aminoglycosides. In: Kaplan LA and Pesce AJ, eds. Clinical Chemistry: Theory, Analysis & Correlation, 5th ed. St. Louis, MO: Mosby. 2009
  • Meany DL and Clarke W: Lithium. In: Kaplan LA and Pesce AJ, eds. Clinical Chemistry: Theory, Analysis & Correlation, 5th ed. St. Louis, MO: Mosby. 2009

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