H. Brent Clark M.D., Ph.D.
K-106 Diehl Hall
505 Essex St SE
Minneapolis, MN 55455
Director, Neuropathology Services at UMMC Fairview
In addition to a full-time practice at University of Minnesota Medical Center, Fairview, Dr. Clark is a consultant at Hennepin County Medical Center and the Minneapolis Veterans Affairs Medical Center. He is active in the teaching of pathology residents on both the anatomic pathology and neuropathology specialty rotations. Residents from the Departments of Neurology and Neurosurgery rotate on his service and he teaches a lecture series for both programs. He also directs the neuropathology section of the second year medical student pathology course.
Dr. Clark’s research activities involve pathological studies of cerebellar ataxia both in human disease and experimental animal models. He is involved as co-investigator on two NIH grants related to investigation of animal models of spino-cerebellar ataxia type 1 and co-investigator on an NIH program project grant studying the CNS aspects of myotonic dystrophy.
- Washington University School of Medicine, St. Louis, MO (1978), M.D./Ph.D.
- Barnes Hospital / Washington University, St. Louis, MO (1982), Residency (Anatomic Pathology and Neuropathology)
Anatomic Pathology, Neuropathology
Dr. Clark has written on a number of subjects, including ataxia, middle cerebral artery dissection, tauopathies, treatment of brain tumors with stereotactic radiosurgery, and increased expression of nitric oxide synthase and cyclo-oxygenase-2 related to cerebral ischemic injury. He is a member of the Editorial Board of Brain Pathology, Journal of Neuropathology and Experimental Neurology, Acta Neuropathologica and Neurobiology of Disease.
- Charizanis K, Lee K-Y, Batra R, Goodwin M, Zhang C, Yuan Y, Shiue L, Cline M, Scotti, MM, Xia G, Kumar A, Ashizawa T, Clark HB, Kimura T, Takahashi MP, Fujimura H, Jinnai K, Yoshikawa H, Gomez-Pereira M, Gourdon G, Sakai N, Nishino S, Ares M, Darnel RB, and Swanson MS: Muscleblind-Like 2 Mediated Alternative Splicing in the Developing Brain and Dysregulation in Myotonic Dystrophy. Neuron 75(3):437-450, 2012.
- Ingram MAC, Orr HT and Clark HB: Genetically engineered mouse models of trinucleotide-repeat spinocerebellar ataxias. Brain Research Bulletin 88:33-42, 2012.
- Paciorkowski AR, Shafrir Y, Hrivnak J, Patterson MC, Tennison MB, Clark HB, Dobyns WB, and Gomez CM : Massive expansion of SCA2: A progressive encephalopathy with infantile spasms, retinitis pigmentosa, and autonomic dysfunction. Neurology 77:1055-60, 2011.
- Öz G, Vollmers ML, Nelson CD, Shanley R, Eberly LE, Orr HT and Clark HB: In vivo monitoring of recovery from neurodegeneration in conditional transgenic SCA1 mice. Experimental Neurology 232:290-298, 2011.
- Zu T, Gibbens B, Moncada N, Gomez-Pereira M, Margolis J, Nan Z, Low W, Somia N, Swanson MS, Clark HB, Schmechel S, Gourdon G, Moseley M and Ranum LPW: Non-ATG Initiated Translation Directed by Microsatellite Repeat Expansions. PNAS 108: 260-5, 2011.
- Oz G, Hutter D, Tkác I, Clark HB, Gross MD, Jiang H, Eberly LE, Bushara KO, Gomez CM. Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status. Mov Disord. Jul 15;25(9):1253-61, 2010.
- Zu,T., Duvick, L.A., Kaytor, M.D., Berlinger, M., Zoghbi, H.Y., Clark, HB and Orr, H.T., Recovery from Polyglutamine-Induced Neurodegeneration in Conditional SCA1Transgenic Mice. J Neuroscience 24:8853-8861, 2004.
- Emamian ES, Kaytor MD, Duvick LA, Zu T, Tousey SK, Zoghbi HY, Clark HB and Orr HT. Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice. Neuron 38:375-387, 2003.