What's Inside

LMP Home

Make a Gift to Laboratory Medicine and Pathology

Visit the ALRT Administrative Center

  Home > About Lab Medicine & Pathology > Faculty and Staff > Kris Hogquist, Ph.D.

Kris Hogquist, Ph.D.

MEDPATHOLOGY Kris Hogquist, Ph.D. - Portrait (2006 B/W)
Contact Information

Phone: 612-625-1616
Fax: 612-625-2199




MMC 334 Mayo
420 Delaware St SE
Minneapolis, MN 55455


Research Interests

My lab is primarily interested in T cell development in the thymus. We study how selection processes shape the T cell repertoire to achieve a highly effective and self-tolerant adaptive immune system. Current research is focused on these four topics:

  • Positive selection: This is a crucial stage in T cell development, where MHC restricted progenitors are selected from a random pool. We are systematically studying the gene changes that occur in the T cell progenitor during positive selection and how they support the multiple facets of this event (e.g. survival, migration, allelic exclusion, etc). We are also exploring how cortical epithelial cells support the process of positive selection.
  • Negative selection: One of the ways the immune system copes with self-reactive T cells is to eliminate them from the repertoire. We developed a highly physiologic in vivo mouse model to study the specific antigen presenting cell types involved and the timing and anatomic location of negative selection. We are also exploring why some self- reactive cells undergo apoptosis, but others are selected to become regulatory T cells or NKT cells.
  • Thymic Emigration: The lab is currently interested in the final stages of maturation that occur prior to migration of the progenitor from the thymus to the periphery. We seek to understand how the functional competence of the cell is eventually switched from apoptosis to proliferation, and the signals, molecular factors, and anatomic structures involved in emigration itself. Recent studies have focused heavily on the transcription factor KLF2.
  • The Human T cell repertoire: We have a unique collaboration with a clinical virology group to study immune responses in humans that are at high risk for natural infection with a gamma herpesvirus (Epstein Barr Virus or EBV). In addition to documenting the precise changes that occur during the innate and adaptive immune response to this virus, we are exploring how the pre-immune T cell repertoire in such individuals is predisposed to make a pathologic response to this virus (infectious mononucleosis).

For more information on my research, please visit my lab homepage at http://www.jamequist.umn.edu/.

Educational Background

  • College of St. Catherine, Minnesota (1983), B.A.
  • Washington University, Missouri (1991), Ph.D.

Professional Background

  • Research Assistant, University of Iowa, Laboratory of Richard Lynch, Iowa City, IA, 1983–1986
  • Postdoctoral Fellowship, University of Washington, Laboratory of Michael Bevan, Seattle, WA, 1991–1995
  • Assistant Professor, University of Minnesota, Center for Immunology, Department of Laboratory Medicine and Pathology, Minneapolis, MN, 1995–2001
  • Associate Professor, University of Minnesota, Center for Immunology, Department of Laboratory Medicine and Pathology, Minneapolis, MN, 2001–2006
  • Professor, University of Minnesota, Center for Immunology,  Department of Laboratory Medicine and Pathology, Minneapolis, MN, 2006–present

Professional Memberships

  • Member, NIH Immunobiology/CMI-B Study Section, 2003-2007
  • Member, AAI Committee on the Status of Women, 2002-2004
  • Section Editor, Journal of Immunology, 2000-2004
  • Editorial Board: European Journal of Immunology, 2006-present
  • Past Chair: AAI Nominating Committee, 2005
  • Course Director:  AAI Advanced Course in Immunology, 2008-2009
  • Editorial Board: Journal of Experimental Medicine, 2009-2012
  • Program Chair: American Association of Immunologists, 2009-2012
  • Member, American Association of Immunologists
  • Member, Univ. of MN Center for Immunology and Cancer Center
  • Graduate Faculty, MICAB, MCDB&G, & M.D./Ph.D. Programs, Univ. of MN

Professional Honors

  • Tozer Scholarship, 1979–1983
  • Phi Beta Kappa Honor Society, 1982–1983
  • National Science Foundation Fellowship, 1987
  • JV Satterfield Arthritis Investigator Award, 1995
  • McKnight Professorship, 1996
  • Searle Scholar Award, 1997
  • David M. Brown Endowed Professorship, 2009



  • Wang L, Jameson SC, Hogquist KA. Epidermal Langerhans cells are not required for UV-induced immunosuppression. J Immunol. 2009 Nov 1;183(9):5548-53.
  • Weinreich, M.A., Takada K., Skon, C., Reiner, S.L., Jameson, S.C., and K. A. Hogquist.  KLF2 deficiency in T cells results in unrestrained cytokine production and bystander chemokine receptor upregulation.Immunity, 31:122 (2009)
  • Chu, H.H., Moon, J.J., Takada. K., Pepper M., Molitor, J.A., Schacker, T., Hogquist, K.A., Jameson, S.C., and Marc K. Jenkins  Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naïve polyclonal repertoire. Proc. Natl. Acad. Sci. 106:11241 (2009).
  • Bursch, L.S., Rich, B.E., and K.A. Hogquist. Langerhans cells are not required for the CD8 T cell response to epidermal self antigen. J. Immunol. 182:4657 (2009)
  • McCaughtry T.M., Baldwin T.A., Wilken M.S., and K.A. Hogquist. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J.Exp. Med 205:2575 (2008).
  • McCaughtry T.M., Hogquist K.A.  Central tolerance: what have we learned from mice?  Semin Immunopathol. 30(4):399-409.  (2008).
  • Weinreich, M.A. and K.A. Hogquist.  Thymic emigration: when and how T cells leave home.  Journal of Immunology 181:2265 (2008).
  • Hogquist K.A., Weinreich, M.A., and S.C. Jameson. Kruppeled T cells move again, Immunology and Cell Biology 86:297 (2008).
  • Wang, L., Bursch, L.S., Kissenpfennig, A., Malissen, B., Jameson, S.C., and K.A. Hogquist.  Langerin expressing cells promote skin immune responses under defined conditions. J. Immunol. 180:4722 (2008).
  • Bursch, L.S., Wang, L., Igyarto, B., Kissenpfennig, A., Malissen, B., Kaplan, D.H., and K.A. Hogquist. Identification of a novel population of Langerhans cells. 204:3417, J. Exp. Med. (2007)
  • McCaughtry T.M., Wilken, M.S., and K.A. Hogquist. Thymic Emigration Revisited. J. Exp. Med.  204:2513 (2007)
  • Baldwin T.A. and K.A. Hogquist. Transcriptional analysis of clonal deletion in vivo. J. Immunol. 179:837(2007)
  • Carlson, C.M., Endrizzi, B.T., Ding, X., Weinreich, M., Walsh, E.R., Wu, J., Wani, M.A., Lingrel, J.B., Hogquist, K.A., and S.C. Jameson.  Lung Kruppel-like factor (KLF2) regulates thymocyte and T cell migration. Nature 442:299 (2006).
  • Mayerova, D, Wang, L., and K. A. Hogquist.  Conditioning of Langerhans cells induced by a primary CD8 T cell response to self-antigen in vivo.  J. Immunol. 176:4658 (2005).
  • McNeil, L.K., Starr, T.K., and K. A. Hogquist. A requirement for sustained ERK signaling during thymocyte positive selection in vivo.  Proc. Natl. Acad. Sci. 102:13574 (2005)
  • Baldwin, T.A., Sandau, M.M, Jameson, S.C., and  K.A. Hogquist. The timing of TCR? expression critically influences T cell development and selection. J. Exp. Med. 202:111 (2005)
  • Hogquist K.A., Baldwin T.A. and S.C. Jameson.  Central Tolerance: Learning Self Control in the Thymus.  Nature Reviews Immunology 5:772 (2005).
  • Baldwin, T.A., Starr, T.K., and K. A. Hogquist. Murine Models of Negative Selection. The Mouse in Biomedical Research In Press (2005)
  • Tze, L.T., Lam, K.P., Hogquist, K.A., Hippen K.L., Liu, J., Rodine P.R., Shinton, S.A., Vegoe, A.L., Hardy R.R., Rajewsky, K. and T.W. Behrens. Basal immunoglobulin signaling maintains allelic exclusion and developmental stage in immature B cells. PLOS 3:e82 (2005)
  • Mick, V.E., Starr, T.K., McCaughtry, T.M., McNeil, L.K., and K.A. Hogquist. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo.  J. Immunol.  173:5434 (2004).
  • Mayerova, D., Parke, E.A., Bursch, L.S., Odumade, O.A., and K.A. Hogquist. Langerhans cells activate naïve self-antigen specific CD8 T cells in the steady state.  Immunity 21:391 (2004)
  • D. Mayerova and K.A. Hogquist. Central tolerance to self-antigen expressed by cortical epithelial cells. J.  Immunol. 172:851 (2004).
  • Hogquist, KA, TA Baldwin, and SC Jameson.  The fourth way?  Harnessing aggressive tendencies in the thymus.  J. Immunol.  173:6515 (2004).

    For a full list of Dr. Hogquist's publications, please see the National Library of Medicine's PubMed search.

Invited Lectures

  • 04/08/03 Pathology Seminar Series, “The T cells’ changing perception of self”. Case Western Reserve University, Cleveland, OH
  • 04/14/03 Microbiology & Immunology Seminar Series. “The T cells’ changing perception of self”. University of Illinois, Chicago, IL
  • 09/28/03 UA Immunology Network. “Receptor Editing and Autoimmunity”. University of Alberta, Edmonton, Alberta, Canada
  • 04/05/04 Immunology Seminar. “The CD8 T cell response to self-antigen”. Memorial Sloan Kettering Cancer Center, New York, NY
  • 05/27/04 Immunology and Virology Seminar. “The CD8 T cell response to self-antigen”. University of Massachusetts, Worcester, MA
  • 09/23/04 Immunology Seminar Series. “The CD8 T cell response to self-antigen” Mayo Clinic, Rochester, MN
  • 10/07/04 4th Annual Buffalo Conference on Immunology. “TCR transgenic models of lymphocyte development”. University of Rochester, Buffalo, NY
  • 11/23/04 Microbiology-Immunology Seminar Series. “The CD8 T cell response epidermal to self-antigens”. Northwestern University, Chicago, IL
  • 12/14/04 Department of Immunology Seminar Series. “The CD8 T cell response epidermal to self-antigens”. Duke University, Durham, NC
  • 01/10/05 Charles Gould Easton Seminar Series. “The CD8 T cell response epidermal to self-antigens”. University of Toronto, Toronto, Canada
  • 04/13/05 Interdisciplinary Program in Immunology. “Getting the TCR to work on time”. University of Iowa, Iowa City, IA. ***Student Invited Seminar
  • 05/05/05 Immunology Seminar Series. “Getting the TCR to work on time”. University of California Irvine, Irvine, CA
  • 12/15/05 Immunology Seminar Series. “The genetic events underlying thymic selection”. New York University (NYU), New York, New York
  • 02/22/06 Immunology Affinity Group. “The genetic events underlying thymic selection”. Scripps Research Institute, La Jolla, CA
  • 03/02/06 Cancer and Allied Disease Seminar Series. “The genetic events underlying thymic selection”. University of Nebraska, Omaha
  • 03/06/06 Pathology Special Seminar. “Tolerance to Self: the frontline and back-up forces”. University of Iowa, Iowa City, IA
  • 05/18/06 Immunology Seminar Series. “Tolerance to Self: the frontline and back-up forces”. University of Vermont, Burmingham, VT
  • 09/28/06 Immunobiology Seminar Series*. “Thymic development: Exit strategies”. Yale University, New Haven CT *post-doc invited speaker
  • 03/15/07 Gladstone Institute. “Thymic selection: Getting Out Alive”. University of California, San Francisco
  • 03/20/07 Immunology Seminar Series. “Thymic selection: Getting Out Alive”. University of Pennsylvania, Philadelphia
  • 04/16/07 Immunology Seminar Series. “Thymic selection: Getting Out Alive”. Stanford University, Palo Alto, CA
  • 05/17/07 Microbiology and Immunology Seminar Series. “Thymic selection: Getting Out Alive”. University of Alabama, Birmingham, AL
  • 05/23/07 Immunology Interest Group (IIG). “Thymic selection: Getting Out Alive”. National Institutes of Health, Bethesda, MD
  • 03/07 UCLA Immunology Forum. University of California, Los Angeles, CA [Declined]
  • 09/24/07 Immunology Seminar Series. “Thymic selection: Getting Out Alive”. UCSF, San Francisco, CA
  • 09/25/07 Faculty Seminar Series. “Thymic selection: Stayin’ Alive”. UC Berkeley, CA
  • 10/22/07 Center for Cell Biology and Cancer Research. “Thymic selection: Getting Out Alive”. Albany Medical Center, NY
  • 11/01/07 Distinguished Lecture, Research Forum. “Thymic selection: Getting Out Alive”. OMRF, Oklahoma City, OK
  • 02/04/08 Cancer Immunology Special Lecture. “Thymic selection: Getting Out Alive”. University of Michigan, Ann Arbor, MI
  • 03/03/08 Committee on Immunology Seminar Series. “T cell selection in the thymus”. University of Chicago, Chicago, IL
  • 04/14/08 Immunology Council Seminar Series. “T cell selection in the thymus”. Johns Hopkins, Baltimore, MD
  • 05/02/08 Distinguished Alumni Speaker. “T cell selection in the thymus”. Washington University, St. Louis, MO. 1000th Graduate Celebration


  • 05/10/03 American Association of Immunologists, Denver CO. Workshop on Tolerance and Autoimmunity. A CD8-dependent autoimmune disease to an antigen cross-presented by Langerhans cell in the skin.
  • 06/14/03 American Diabetes Association 63rd Scientific Sessions, New Orleans, LA. Symposia on T-Cell Repertoire in Type I Diabetes.  Receptor Editing.
  • 02/11/04 Keystone Symposia: T cell Development. Banff Springs, Canada. Session overview.
  • 06/20/04 FASEB Summer Conf., Lymphocytes and Antibodies, Saxton Rivers, VT. The CD8 response to self-antigens.
  • 07/22/04 Early lymphocyte, 12th International Congress of Immunology, Montreal, Canada. The effects of “on-time” TCR expression.
  • 03/04/05 Keystone Symposia, Immune Tolerance and Homeostasis, Keystone, CO. The timing of TCRa rearrangement critically influences development.
  • 05/21/05 The Genetic Basis of Immune Tolerance, Gwen Knapp Symposium, Chicago, IL. For self-reactive T cells: the death sentence is not mandatory.
  • 08/21/05 Genetic Control of T cell Activation, Lofoten Islands, Norway. Positive and negative selection of T cells, Timing is everything.
  • 09/19/05 Honorary Symposium for Michael J. Bevan, Seattle, WA. Positive selection of T cells.
  • 11/18/05 Symposia on Thymic Selection, Chair, AIC, Chicago, IL. Gene changes that drive thymic selection.
  • 03/21/06 Keystone Symposia on Tolerance and Autoimmunity, Breckenridge, CO. The genetic changes that drive thymic selection.
  • 08/16/06 Chinese Academy of Science Symposium, Kunming, China. KLF2 and thymic emigration.
  • 01/29/07 Midwinter Conference of Immunologists, Asilomar, CA. Thymic development: getting out alive.
  • 07/09/07 FASEB Summer Conference, Lymphocytes and Antibodies, Tucson, AZ. T cell development.
  • 10/21/07 CD8 Club, Amherst MA. Do cortical APC delete?
  • 12/02/07 Australasian Immunology Conference, Sydney, Australia. The fate of self-reactive T cells in the thymus


Notice of Privacy Practices