Amy Karger, MD, PhD

Assistant Professor, Department of Laboratory Medicine and Pathology

Amy Karger

Contact Info

karge026@umn.edu

Office Phone 612-624-2150

Fax 612-899-5614

Mailing Address:
MMC 609 Mayo
8609
420 Delaware SE
Minneapolis, MN 55455

Mayo Clinic College of Medicine, 1998-2006

University of Minnesota (Clinical Pathology), 2008-2011

University of Minnesota (Clinical Chemistry), 2011-2013

PhD, Mayo Clinic College of Medicine (Biomedical Sciences), 1998-2006

Massachusetts Institute of Technology (Chemical Engineering and Biology), 1994-1998

Summary

Dr. Karger is a member of the Division of Molecular Pathology and Genomics and a faculty investigator in the Advanced Research and Diagnostics Laboratory (ARDL). Her research focuses on predicting and delaying the progression of chronic kidney disease. Dr. Karger serves as a principal investigator with the Preventing Early Renal Loss in Diabetes (PERL) consortium. The consortium has undertaken a multi-center, double-blind, placebo-controlled, randomized clinical trial aimed at evaluating the efficacy of allopurinol in preventing kidney function loss in individuals with type 1 diabetes.

Dr. Karger is also a co-investigator with Dr. John Eckfeldt in the chronic kidney disease epidemiology collaboration (CKD-EPI). In this capacity she tests protein biomarkers such as cystatin C, beta-2 microglobulin and beta trace protein to improve GFR estimating equations. Improved GFR estimates give clinicians the ability to detect disease progression at earlier stages. By detecting disease progression at earlier stages clinicians can in turn intervene therapeutically. Delaying renal failure delays the need for dialysis with its many potential complications and high costs.

Research

Publications

  • Gruenberg JM, Stein TA, Karger AB. Determining the utility of creatinine delta checks: A large retrospective analysis. Clin Biochem 2018 Feb 1 pii: S0009-9120(17)31254-7. Doi: 10:1016/j.clinbiochem.2018.01.023. (Epub ahead of print). https://www.ncbi.nlm.nih.gov/pubmed/29402415
  • Karger AB, Inker LA, Coresh J, Levey AS, Eckfeldt JH. Novel Filtration Markers for GFR Estimation. EJIFCC 2017 Dec 19:28(4):277-288.eCollection 2017 Dec. https://www.ncbi.nlm.nih.gov/pubmed/29333147
  • Danni Li, Angela Radulescu, Rupendra T. Shrestha, Matthew Root, Amy B. Karger, Anthony A. Killeen, James S. Hodges, Shu-Ling Fan, Angela Ferguson, Uttam Garg, Lori J. Sokoll, Lynn A. Burmeister. Association of biotin ingestion with performance of hormone and nonhormone assays in healthy adults. JAMA 2017.;318(12):1150-1160.doi:10.1001/jama.2017.13705. https://goo.gl/yeqStZ
  • Cao J, Senn C, Castaneda P, Humphries S, Karger AB. Establishing a stand-alone laboratory dedicated to the care of patients with Ebola virus disease. Lab Med, 2017 Mar 13, doi: 10.1093/labmed/lmw072.
  • Karger AB, Saenger AK. A Setback to Universal Pediatric Lipid Screening and a Call for More Research. Clin Chem Feb 2017, 63 (2) 620-621; DOI: 10.1373/clinchem.2016.267989.
  • Karger AB. To delta check or not to delta check? That is the question...J Appl Lab Med Jan 2017, 1 (4) 457-459; DOI: 10.1373/jalm.2016.022020.
  • American Association for Clinical Chemistry (AACC) Government Relations Committee and AACC’s Pediatric and Maternal-Fetal Division. Advancing Children's Health through Pediatric Laboratory Medicine. Aug. 1, 2016. https://www.aacc.org/health-and-science-policy/aac...
  • Selvaratnam R, Karger AB. A Newborn with Distended Abdomen. PMID: 27471243. Clin Chem 2016 Aug; 62(8) 1061-4.
  • Karger AB, Seen C, Skogseth K, Floodman S. Rare erroneous results on the Siemens Dimension Vista® platform due to urine carryover: A warning to current users. J Clin Biochem DOI:10.1016/j.clinbiochem.2016.05.003 Published online 9 May 2016. http://www.sciencedirect.com/science/article/pii/S0009912016300492
  • Eckfeldt JH, Karger AB, Miller WG, Rynders GP, Inker LA. Performance in measurement of serum cystatin C by laboratories participating in the college of american pathologists 2014 CYS survey. Arch Pathol Lab Med 2015;139:888-893.
  • Holman CJ, Karger AB, Mullan BD, Brundage RC,Balfour HH. Quantitative Epstein-Barr Virus Shedding and Its Correlation with the Risk of Posttransplant Lymphoproliferative Disorder.Clin Transplant 26:741-747, 2012.
  • Karger AB and Killeen AA. Applications of Sanctions by the Centers for Medicare and Medicaid Services and by Accrediting Organizations for Proficiency Testing Failure: A 9-Year Study.Clin Leadersh Manag Rev25:20-24, 2011.
  • Karger AB, Park S, Reyes S, Bienengraeber M, Dyer RB, Terzic
    A, Alekseev AE. Role for SUR2A ED domain in allosteric coupling
    within the KATP channel complex. J Gen Physiol 131:185-196,
    2008.
  • Karger AB, Wilson JD, Bower M, Schimmenti LA, Thyagarajan B. Detection of PAX2 Deletions and Duplications Using Multiplex Ligation-Dependent Probe Amplification. Genet Test Mol Biomarkers 17:786-788, 2013.

Clinical

Board Certifications

American Board of Pathology, Clinical Pathology, 2011