Claudia Cohn, MD, PhD

Associate Professor, Department of Laboratory Medicine and Pathology

Claudia Cohn

Contact Info

cscohn@umn.edu

Office Phone 612-626-2106

Mailing Address:
MMC 609 Mayo Building
8609
420 Delaware Street SE
Minneapolis, MN 55455

Louisiana State University, 2004

Louisiana State University (Anatomic and Clinical Pathology), 2004-2006

Weill Cornell Medical Center, New York (Anatomic and Clinical Pathology), 2006-2009

University of California, San Francisco (Transfusion Medicine), 2009-2010

PhD, Johns Hopkins University (Molecular Biology/Biochemistry), 1994

BA, George Washington University, Washington, D.C. (Biological Sciences), 1986

Summary

Dr. Cohn is Associate Director of Laboratories and Director of the Blood Bank Laboratory.  She conducts research in the field of transfusion medicine. She focuses her efforts in two areas: patient blood management and platelet storage and utilization.

Patient blood management applies evidence-based guidelines to limit unnecessary transfusions and maximize patient safety. Cohn uses technology and smart phone apps to gather data, which can help guide clinicians with transfusion decisions. To help foster a good transfusion culture, Cohn and her colleagues have developed overlapping databases that allow them to monitor every transfusion made in the hospital retrospectively and determine whether they were made within guidelines. Their interactive patient blood management system enables them to specifically target education efforts to where improvement is most needed. A significant drop in red blood cell usage has occurred coincident with the development of this monitoring program aimed at conserving transfusion resources and lowering costs. The interactive and collaborative program Cohn and her colleagues have developed can be tailored for use in small and large hospitals that want to develop a comprehensive patient blood management system. Other institutions have adopted the guidelines they have developed.

Cohn is also interested in new platelet storage options, platelet utilization, and patient immunologic reactions to donor plasma. The University is one of the largest users of platelets in the nation because of the large number of umbilical cord stem cell transplants performed each year. Following FDA approval in 2009, platelets can now be stored in additive solutions in addition to donor plasma. Platelets stored in additive solutions are less frequently involved in transfusion reactions because donor plasma contains cytokines, allergens, and other molecules that can trigger these immunologic reactions. Some patients develop antibodies to class I HLA molecules on platelet surfaces and are refractory to conventional donor platelet transfusions. In her capacity as associate director of the HLA Laboratory, Cohn’s group is investigating whether these patients can be identified in advance of transfusion.

Research

Publications

  • Sackett K, Cohn CS, Fahey-Ahrndt K, Smith AR, Johnson AD.  Successful treatment of pure red cell aplasia because of ABO major mismatched stem cell transplant. J Clin Apher. 2017 May 24. doi: 10.1002/jca.21553. [Epub ahead of print] PMID:28543448
  • Johnson AD, Cohn CS.  Xenotropic Murine Leukemia Virus-Related Virus (XMRV) and the Safety of the Blood Supply.  Clin Microbiol Rev. 2016 Oct; 29(4):749-57
  • Dzik WS, Ziman A, Cohn CS, Pai M, Lozano M, Kaufman R, Delaney M, Selleng K, Murphy M, Hervig T, Yazer M for the BEST Collaborative. Survival following ultra-massive transfusion: a review of 1360 cases. Transfusion 2016 Mar; 56(3):558-63. 
  • Cohn CS, Lockhart E. Autologous Platelet-Rich Plasma: Evidence for Clinical Use. Current Opinions in Hematology. Accepted in July, 2015.
  • Yulia Lin, Alan Tinmouth, Ranjeeta Mallick, Richard L. Haspel, for the BEST-TEST Investigators BEST-TEST2: Assessment of Hematology Trainee Knowledge of Transfusion Medicine. Accepted in Transfusion, July 2015.
  • Ustun, Celalettin, Laura E. Lunde, Sandhya Dasaraju, Qing Cao, Claudia S. Cohn, Mark Reding, Nelli Bejanyan, Erica Warlick, Jo Anne H. Young, Daniel J. Weisdorf. Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival. Accepted in Bone Marrow Transplantation, April, 2015
  • Cohn CS, LockCohn CS, Stubbs J, Schwartz J, Francis R, Goss C, Cushing M, Shaz B, Mair D, Brantigan B, Heaton WA. A comparison of adverse reaction rates for PAS?C versus plasma platelet units. Transfusion. 2014 54(8):1927-34. doi: 10.1111/trf.12597. Epub 2014 Apr 16. PMID:24735171
  • Cohn CS, Welbig J, Bowman R, Kammann S, Frey K, Zantek N. A data-driven approach to patient blood management. Transfusion. 2014 54(2):316-22. doi: 10.1111/trf.12276. Epub 2013 Jun 17. PMID: 2377266
  • Rioux-Massé, Benjamin; Laroche, Vincent; Bowman, Robert J.; Lindgren, Bruce R.; Cohn, Claudia S.; Pulkrabek, Shelley M.; McCullough, Jeffrey. The influence of bleeding on trigger changes for platelet transfusion in patients with chemotherapy-induced thrombocytopenia. Transfusion 53(2) 306-314.2013 PMID: 22670810
  • Bollag, Roni J.; Sterett, Meghan; Reding, Mark T.; Key, Nigel; Cohn, Claudia S.; Üstün, Celalettin Response of complex immune-mediated thrombocytopenia to romiplostim in the setting of allogeneic stem cell transplantation for chronic myelogenous leukemia. European Journal of Haematology. 89(4):361-364 2012 PMID: 22775392
  • Zantek, Nicole Dodge; Koepsell, Scott A.; Tharp, Daryl R.; Cohn, Claudia S. The direct antiglobulin test: A critical step in the evaluation of hemolysis. American Journal of Hematology 87(7) 707-709 2012 PMID: 22566278

Clinical

Board Certifications

Clinical Pathology, Transfusion Medicine / Blood Banking