Kristin A. Hogquist, PhD

Professor, Department of Laboratory Medicine and Pathology

Kristin A. Hogquist

Contact Info

hogqu001@umn.edu

Office Phone 612-625-1616

Fax 612-625-2199

Lab Phone 612-625-1626

Office Address:
Lab Medicine and Pathology
2-186 MBB
2101 6th Street SE
Minneapolis, MN 55414

Mailing Address:
Center for Immunology
Department of Lab Medicine & Pathology
University of Minnesota
2101 6th Street SE
Minneapolis, MN 55414
Campus Delivery Code: 2641

University of Washington, 1991-1995

PhD, Washington University, 1991

BA, College of St. Catherine, 1983

Summary

My lab is primarily interested in T cell development in the thymus. We study how selection processes shape the T cell repertoire to achieve a highly effective and self-tolerant adaptive immune system.

Expertise

T cell development in the thymus

Awards & Recognition

  • Tozer Scholarship, 1979–1983
  • Phi Beta Kappa Honor Society, 1982–1983 
  • National Science Foundation Fellowship, 1987 
  • JV Satterfield Arthritis Investigator Award, 1995 
  • McKnight Professorship, 1996 
  • Searle Scholar Award, 1997 
  • David M. Brown Endowed Professorship, 2009

Professional Associations

Member, NIH Immunobiology/CMI-B Study Section, 2003-2007 Member, AAI Committee on the Status of Women, 2002-2004 Section Editor, Journal of Immunology, 2000-2004 Editorial Board: European Journal of Immunology, 2006-present Past Chair: AAI Nominating Committee, 2005 Course Director: AAI Advanced Course in Immunology, 2008-2009 Editorial Board: Journal of Experimental Medicine, 2009-2012 Program Chair: American Association of Immunologists, 2009-2012 Member, Ameri

Research

Research Summary/Interests

Primarily interested in T cell development in the thymus. We study how selection processes shape the T cell repertoire to achieve a highly effective and self-tolerant adaptive immune system. Current research is focused on these four topics:

Positive selection: This is a crucial stage in T cell development, where MHC restricted progenitors are selected from a random pool. We are systematically studying the gene changes that occur in the T cell progenitor during positive selection and how they support the multiple facets of this event (e.g. survival, migration, allelic exclusion, etc). We are also exploring how cortical epithelial cells support the process of positive selection

Negative selection: One of the ways the immune system copes with self-reactive T cells is to eliminate them from the repertoire. We developed a highly physiologic in vivo mouse model to study the specific antigen presenting cell types involved and the timing and anatomic location of negative selection. We are also exploring why some self- reactive cells undergo apoptosis, but others are selected to become regulatory T cells or NKT cells.

Thymic Emigration: The lab is currently interested in the final stages of maturation that occur prior to migration of the progenitor from the thymus to the periphery. We seek to understand how the functional competence of the cell is eventually switched from apoptosis to proliferation, and the signals, molecular factors, and anatomic structures involved in emigration itself. Recent studies have focused heavily on the transcription factor KLF2.

The Human T cell repertoire: We have a unique collaboration with a clinical virology group to study immune responses in humans that are at high risk for natural infection with a gamma herpesvirus (Epstein Barr Virus or EBV). In addition to documenting the precise changes that occur during the innate and adaptive immune response to this virus, we are exploring how the pre-immune T cell repertoire in such individuals is predisposed to make a pathologic response to this virus (infectious mononucleosis).

Publications

  • Grimm, J.M., D.O. Schmeling, S.K. Dunmire, J.A. Knight, B.D. Mullan, J.A. Ed, R.C. Brundage, K.A. Hogquist and H.H. Balfour Jr. “Prospective studies of infectious mononucleosis in university students,” Clinical & Translational Immunology (2016) 5, e94; doi:10.1038/cti.2016.48. 
  • Lee YJ, Starrett GJ, Lee ST, Yang R, Henzler CM, Jameson SC, Hogquist KA. Lineage-Specific Effector Signatures of Invariant NKT Cells Are Shared amongst ?? T, Innate Lymphoid, and Th Cells. J Immunol. 2016 Aug 15;197(4):1460-70. doi: 10.4049/jimmunol.1600643. Epub 2016 Jul 6.
  • Xing Y, Wang X, Jameson SC, Hogquist KA. Late stages of T cell maturation in the thymus involve NF-?B and tonic type I interferon signaling. Nat Immunol. 2016 May;17(5):565-73. doi: 10.1038/ni.3419. Epub 2016 Apr 4.
  • Wang H, Hogquist KA. How MAIT cells get their start. Nat Immunol. 2016 Oct 19;17(11):1238-1240. doi: 10.1038/ni.3584.
  • Dunmire SK, Grimm JM, Schmeling DO, Balfour HH Jr, Hogquist KA.The Incubation Period of Primary Epstein-Barr Virus Infection: Viral Dynamics and Immunologic Events. PLoS Pathog. 2015 Dec 1;11(12):e1005286.
  • Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA.
    Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response. Immunity. 2015 Sep 15;43(3):566-78.
  • Fulton, R.B.,Y. Xing, J.A. Best, A.W. Goldrath, K.A. Hogquist and S.C. Jameson. (2015) TCR sensitivity to self-peptide-MHC dictates naïve CD8 T-cells’ capacity to respond to foreign antigens. Nat.Imm. 16:107-117
  • Lee, J.-Y., C.N. Skon, Y.J. Lee, S. Oh, J.J. Taylor, D. Malhotra, M.K. Jenkins, M.G. Rosenfeld, K.A. Hogquist and S.C. Jameson. (2015) The transcription factor KLF2 restrains CD4+ T follicular helper cell differentiation. Immunity 42:252-264
  • Lee YJ, Holzapfel KL, Zhu J, Jameson SC, and KA Hogquist. 2013. Steady state production of IL-4 modulates immunity in different strains and is determined by lineage diversity of iNKT cells. Nature Immunology 14:1146.
  • Xing Y, Jameson SC, and KA Hogquist. 2013. The thymoproteasome subunit ?5T generates pMHC specialized for positive selection. Proc Natl Acad Sci U S A. 110:6979.
  • Stritesky GL, Xing Y, Erickson JR, Kalekar LA, Mueller DM, Jameson SC, and KA Hogquist. 2013. Murine thymic selection quantified using a novel method to capture deleted T cells. Proc Natl Acad Sci U S A. 110:4679.
  • Balfour, HH, Odumade, O.A. Schmeling, D.O., Mullan, BD, Ed, JA, Knight, JA, Vezina, HE, Thomas, W and KA Hogquist. 2013. Virologic, and Immunologic Factors Associated with Acquisition and Severity of Primary Epstein-Barr Virus Infection in University Students. J. Inf. Dis. 207(01):80-8.
  • Lee YJ, Holzapfel KL, Zhu J, Jameson SC, and KA Hogquist. Steady state production of IL-4 modulates immunity in different strains and is determined by lineage diversity of iNKT cells. (2013) Nature Immunology 14:1146.
  • Skon, C.N., J.Y. Lee, K.G. Anderson, D. Masopust, K.A. Hogquist, and S.C. Jameson. (2013) Transcriptional downregulation of S1PR1 is required for establishment of resident memory CD8+ T-cells. Nature Immunology. 14:1285-1293
  • Fulton, R.B.,Y. Xing, J.A. Best, A.W. Goldrath, K.A. Hogquist and S.C. Jameson. (2014) TCR sensitivity to self-peptide-MHC dictates naïve CD8 T-cells’ capacity to respond to foreign antigens. Nat.Imm. 16:107-117
  • REVIEW: Stritesky GL, Jameson SC, Hogquist KA. 2012. Selection of self-reactive T cells in the thymus. Annu Rev Immunol. 30:95.
  • Odumade, O.A., Knight, J.A., Schmeling, D.O., Masopust D., Balfour, H.H. Jr., and K.A. Hogquist. 2012. Primary Epstein-Barr virus infection does not erode pre-existing CD8 T cell memory in humans. J. Exp. Med. 209:471.
  • Moran, A.E., Holzapfel K.L. Xing, Y., Cunningham, N.R., Maltzman, J.S., Punt, J., and K.A. Hogquist. 2011. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med.208:1279.
  • REVIEW: Lee, Y.J., Jameson, S.C., and K.A. Hogquist. 2011. Alternative memory in the CD8 lineage. Trends in Immunology 32:50.
  • Weinreich, M.A., Jameson S.C., and K.A. Hogquist. 2011. Post- selection thymocyte maturation and emigration are independent of IL-7 and ERK5. J Immunol. 186:1343.
  • REVIEW: Odumade, O.A., Hogquist, K.A., and H. J. Balfour III. 2011. Progress and Problems in Understanding and Managing Epstein-Barr Virus Infections. Clin Microbiol Rev 24:193.
  • Weinreich, M.A., Odumade, O.A., Jameson S.C., and K.A. Hogquist. 2010. PLZF+ T cells regulate memory-like CD8 T cell development. Nature Immunology, 11:709.
  • Odumade, O.A., Weinreich M.A., Jameson S.C., and K.A. Hogquist. 2010. Kruppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells. J. Immunol. 184:6060.
  • Wang L., Jameson, S.C., and K.A. Hogquist. 2009. Epidermal Langerhans cells are not required for UV induced immunosuppression. J. Immunol. 183:5548.
  • Weinreich, M.A., Takada K., Skon, C., Reiner, S.L., Jameson, S.C., and K. A. Hogquist. 2009. KLF2 deficiency in T cells results in unrestrained cytokine production and bystander chemokine receptor upregulation.Immunity, 31:122.
  • Bursch, L.S., Rich, B.E., and K.A. Hogquist. 2009. Langerhans cells are not required for the CD8 T cell response to epidermal self antigen. J. Immunol. 182:4657.
  • Wang L, Jameson SC, Hogquist KA. Epidermal Langerhans cells are not required for UV-induced immunosuppression. J Immunol. 2009 Nov 1;183(9):5548-53.
  • Weinreich, M.A., Takada K., Skon, C., Reiner, S.L., Jameson, S.C., and K. A. Hogquist. KLF2 deficiency in T cells results in unrestrained cytokine production and bystander chemokine receptor upregulation.Immunity, 31:122 (2009)
  • Chu, H.H., Moon, J.J., Takada. K., Pepper M., Molitor, J.A., Schacker, T., Hogquist, K.A., Jameson, S.C., and Marc K. Jenkins Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naïve polyclonal repertoire. Proc. Natl. Acad. Sci. 106:11241 (2009).
  • Bursch, L.S., Rich, B.E., and K.A. Hogquist. Langerhans cells are not required for the CD8 T cell response to epidermal self antigen. J. Immunol. 182:4657 (2009)
  • McCaughtry T.M., Baldwin T.A., Wilken M.S., and K.A. Hogquist. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J.Exp. Med 205:2575 (2008).
  • McCaughtry T.M., Hogquist K.A. Central tolerance: what have we learned from mice? Semin Immunopathol. 30(4):399-409. (2008).
  • Weinreich, M.A. and K.A. Hogquist. Thymic emigration: when and how T cells leave home. Journal of Immunology 181:2265 (2008).
  • Hogquist K.A., Weinreich, M.A., and S.C. Jameson. Kruppeled T cells move again, Immunology and Cell Biology 86:297 (2008).
  • Wang, L., Bursch, L.S., Kissenpfennig, A., Malissen, B., Jameson, S.C., and K.A. Hogquist. Langerin expressing cells promote skin immune responses under defined conditions. J. Immunol. 180:4722 (2008).
  • Bursch, L.S., Wang, L., Igyarto, B., Kissenpfennig, A., Malissen, B., Kaplan, D.H., and K.A. Hogquist. Identification of a novel population of Langerhans cells. 204:3417, J. Exp. Med. (2007)
  • McCaughtry T.M., Wilken, M.S., and K.A. Hogquist. Thymic Emigration Revisited. J. Exp. Med. 204:2513 (2007)
  • Baldwin T.A. and K.A. Hogquist. Transcriptional analysis of clonal deletion in vivo. J. Immunol. 179:837(2007)
  • Carlson, C.M., Endrizzi, B.T., Ding, X., Weinreich, M., Walsh, E.R., Wu, J., Wani, M.A., Lingrel, J.B., Hogquist, K.A., and S.C. Jameson. Lung Kruppel-like factor (KLF2) regulates thymocyte and T cell migration. Nature 442:299 (2006).
  • Mayerova, D, Wang, L., and K. A. Hogquist. Conditioning of Langerhans cells induced by a primary CD8 T cell response to self-antigen in vivo. J. Immunol. 176:4658 (2005).
  • McNeil, L.K., Starr, T.K., and K. A. Hogquist. A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc. Natl. Acad. Sci. 102:13574 (2005)
  • Baldwin, T.A., Sandau, M.M, Jameson, S.C., and K.A. Hogquist. The timing of TCR? expression critically influences T cell development and selection. J. Exp. Med. 202:111 (2005)
  • Hogquist K.A., Baldwin T.A. and S.C. Jameson. Central Tolerance: Learning Self Control in the Thymus. Nature Reviews Immunology 5:772 (2005).
  • Baldwin, T.A., Starr, T.K., and K. A. Hogquist. Murine Models of Negative Selection. The Mouse in Biomedical Research In Press (2005)
  • Tze, L.T., Lam, K.P., Hogquist, K.A., Hippen K.L., Liu, J., Rodine P.R., Shinton, S.A., Vegoe, A.L., Hardy R.R., Rajewsky, K. and T.W. Behrens. Basal immunoglobulin signaling maintains allelic exclusion and developmental stage in immature B cells. PLOS 3:e82 (2005)
  • Mick, V.E., Starr, T.K., McCaughtry, T.M., McNeil, L.K., and K.A. Hogquist. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J. Immunol. 173:5434 (2004).
  • Mayerova, D., Parke, E.A., Bursch, L.S., Odumade, O.A., and K.A. Hogquist. Langerhans cells activate naïve self-antigen specific CD8 T cells in the steady state. Immunity 21:391 (2004)
  • D. Mayerova and K.A. Hogquist. Central tolerance to self-antigen expressed by cortical epithelial cells. J. Immunol. 172:851 (2004).
  • Hogquist, KA, TA Baldwin, and SC Jameson. The fourth way? Harnessing aggressive tendencies in the thymus. J. Immunol. 173:6515 (2004).

For a full list of Dr. Hogquist's publications, please see the National Library of Medicine's PubMed search.

Invited Lectures

  • 04/08/03 Pathology Seminar Series, “The T cells’ changing perception of self”. Case Western Reserve University, Cleveland, OH
  • 04/14/03 Microbiology & Immunology Seminar Series. “The T cells’ changing perception of self”. University of Illinois, Chicago, IL
  • 09/28/03 UA Immunology Network. “Receptor Editing and Autoimmunity”. University of Alberta, Edmonton, Alberta, Canada
  • 04/05/04 Immunology Seminar. “The CD8 T cell response to self-antigen”. Memorial Sloan Kettering Cancer Center, New York, NY
  • 05/27/04 Immunology and Virology Seminar. “The CD8 T cell response to self-antigen”. University of Massachusetts, Worcester, MA
  • 09/23/04 Immunology Seminar Series. “The CD8 T cell response to self-antigen” Mayo Clinic, Rochester, MN
  • 10/07/04 4th Annual Buffalo Conference on Immunology. “TCR transgenic models of lymphocyte development”. University of Rochester, Buffalo, NY
  • 11/23/04 Microbiology-Immunology Seminar Series. “The CD8 T cell response epidermal to self-antigens”. Northwestern University, Chicago, IL
  • 12/14/04 Department of Immunology Seminar Series. “The CD8 T cell response epidermal to self-antigens”. Duke University, Durham, NC
  • 01/10/05 Charles Gould Easton Seminar Series. “The CD8 T cell response epidermal to self-antigens”. University of Toronto, Toronto, Canada
  • 04/13/05 Interdisciplinary Program in Immunology. “Getting the TCR to work on time”. University of Iowa, Iowa City, IA. ***Student Invited Seminar
  • 05/05/05 Immunology Seminar Series. “Getting the TCR to work on time”. University of California Irvine, Irvine, CA
  • 12/15/05 Immunology Seminar Series. “The genetic events underlying thymic selection”. New York University (NYU), New York, New York
  • 02/22/06 Immunology Affinity Group. “The genetic events underlying thymic selection”. Scripps Research Institute, La Jolla, CA
  • 03/02/06 Cancer and Allied Disease Seminar Series. “The genetic events underlying thymic selection”. University of Nebraska, Omaha
  • 03/06/06 Pathology Special Seminar. “Tolerance to Self: the frontline and back-up forces”. University of Iowa, Iowa City, IA
  • 05/18/06 Immunology Seminar Series. “Tolerance to Self: the frontline and back-up forces”. University of Vermont, Burmingham, VT
  • 09/28/06 Immunobiology Seminar Series*. “Thymic development: Exit strategies”. Yale University, New Haven CT *post-doc invited speaker
  • 03/15/07 Gladstone Institute. “Thymic selection: Getting Out Alive”. University of California, San Francisco
  • 03/20/07 Immunology Seminar Series. “Thymic selection: Getting Out Alive”. University of Pennsylvania, Philadelphia
  • 04/16/07 Immunology Seminar Series. “Thymic selection: Getting Out Alive”. Stanford University, Palo Alto, CA
  • 05/17/07 Microbiology and Immunology Seminar Series. “Thymic selection: Getting Out Alive”. University of Alabama, Birmingham, AL
  • 05/23/07 Immunology Interest Group (IIG). “Thymic selection: Getting Out Alive”. National Institutes of Health, Bethesda, MD
  • 03/07 UCLA Immunology Forum. University of California, Los Angeles, CA [Declined]
  • 09/24/07 Immunology Seminar Series. “Thymic selection: Getting Out Alive”. UCSF, San Francisco, CA
  • 09/25/07 Faculty Seminar Series. “Thymic selection: Stayin’ Alive”. UC Berkeley, CA
  • 10/22/07 Center for Cell Biology and Cancer Research. “Thymic selection: Getting Out Alive”. Albany Medical Center, NY
  • 11/01/07 Distinguished Lecture, Research Forum. “Thymic selection: Getting Out Alive”. OMRF, Oklahoma City, OK
  • 02/04/08 Cancer Immunology Special Lecture. “Thymic selection: Getting Out Alive”. University of Michigan, Ann Arbor, MI
  • 03/03/08 Committee on Immunology Seminar Series. “T cell selection in the thymus”. University of Chicago, Chicago, IL
  • 04/14/08 Immunology Council Seminar Series. “T cell selection in the thymus”. Johns Hopkins, Baltimore, MD
  • 05/02/08 Distinguished Alumni Speaker. “T cell selection in the thymus”. Washington University, St. Louis, MO. 1000th Graduate Celebration