Lihong Bu, MD, PhD

Assistant Professor, Department of Laboratory Medicine and Pathology

Lihong Bu

Contact Info

lbu@umn.edu

Office Phone 612-273-3447

Mailing Address:
MMC 76 Mayo
8076A (Campus Delivery Code)
420 Delaware St. SE
Minneapolis, MN 55455

China Medical University, China, 1997

UT Southwestern, 2014

Cedars-Sinai Medical Center (Renal Pathology), 2015

PhD, Brigham Young University (Neuroscience/Physiology and Developmental Biology), 2005

Summary

Dr. Bu is an anatomic pathologist with special research interests in kidney pathology including kidney transplant rejection. Her doctoral research focused on the role of the hormones estrogen and phytoestrogen, an estrogen mimic, in brain development. Specifically, Bu and her colleagues measured the consumption of phytoestrogen versus phytoestrogen-free diets from conception to adulthood in laboratory animals. They found that serum phytoestrogen levels were significantly increased in the phyto-fed animals compared to the phyto-free animals, which affected brain structure formation. They concluded that the consumption of dietary phytoestrogens can alter hormone-sensitive hypothalamic brain volumes in rodents during adulthood, which affects learning and memory. Bu then studied the role of the adhesion G-protein coupled receptor 56 (GPR-56) gene, which provides instructions for making a protein that is critical for normal brain development. Subsequently, she worked with a team that established pathologic parameters using biomarkers in prostate cancer.


More recently, Bu has shifted her research activities to renal pathologies including membranous nephropathy, a common renal disease resulting in proteinuria, and the role of phospholipase A2 receptor (PLA2R) in membranous nephropathy associated with pregnancy. Bu has a strong research interest in kidney transplant rejection, in particular vascular rejection. She looks forward to collaborating with clinicians in this research endeavor given the University’s strength in the kidney transplantation field.

Research

Publications

  • Kim J, Bu L, Koduru P, Wilson K, Fuda F, Kumar K, Timmons C, Slone T. Novel r(2)(p25q31) cytogenetic abnormality in a pediatric patient with acute leukemia of ambiguous lineage. Pediatr Dev Pathol. In press. (IF 0.86; Developed study concept, data acquisition, manuscript editing, review)
  • Edlow BL, Takahashi E, Wu O, Benner T, Dai G, Bu L, Grant PE, Greer DM, Greenberg SM, Kinney HC, Folkerth RD. Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders. J Neuropathol Exp Neurol. 2012; 71(6):531-46. (IF 4.372; Conducted experimental studies, manuscript editing, review)
  • Lund TD, Blake C, Bu L, Hamaker AN, Lephart ED. Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence. Reprod Biol Endocrinol. 2011; 9:4 (IF 2.41; Conducted experimental studies)
  • Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci. 2008; 28(22): 5817-26. (IF 7.87; Developed study concept, developed study design, conducted experimental studies)
  • Jin Z, Tietjen I, Bu L, Liu-Yesucevitz L, Caur SK, Walsh CA, Piao X. Disease-associated mutations affect GPR56 protein trafficking and cell surface expression. Hum Mol Genet. 2007; 16(16): 1972-85. (IF 6.968; Conducted experimental studies)
  • Bu L, Lephart ED. AVPV neurons containing estrogen receptor-beta in adult male rats are influenced by soy isoflavones. BMC Neurosci. 2007;8:13. (IF2.85; Guarantor of integrity of entire study)
  • Bu L, Lephart ED. Regulatory behavior and skin temperature in mid-aged male rats on three different isoflavone-containing diets. J Med Food 2006;9: 567–571. (IF 1.699; Guarantor of integrity of entire study)

Clinical

Board Certifications

Anatomic Pathology, American Board of Pathology