Myron Gross, PhD

Professor, Department of Laboratory Medicine and Pathology

Myron Gross

Contact Info

gross001@umn.edu

Office Phone 612-624-5417

Fax 612-625-8950

Mailing Address:
MMC 609 Mayo
8609
420 Delaware
Minneapolis, MN 55455

PhD, University of Minnesota (Human Nutrition/Biochemistry), 1985

MS, North Dakota State University (Animal Science), 1977

BS, North Dakota State University (Animal Science), 1974

Summary

Dr. Gross directs the Molecular Epidemiology and Biomarker Research Laboratory (MEBRL) and is a faculty investigator in the Advanced Research and Diagnostic Laboratory (ARDL). MEBRL acts as the central laboratory for several studies wherein he applies biochemical, immunologic and genetic mass spectrometry (MS) and other techniques to the discovery, development, and application of biomarkers in cardiovascular disease, diabetes, and cancer. Special emphasis is placed on mass spectrometry that allows for a highly precise characterization of biomarkers.

Dr. Gross and his research team specialize in conducting analyses for large epidemiologic studies with the goal of defining new risk factors and understanding the pathophysiology of the conditions. One of his areas of interest is the interplay of diet and chronic disease, in particular, the role of oxidative cellular damage and antioxidant micronutrients in cardiovascular disease risk and prevention. He has also explored the association between oxidative stress biomarkers and insulin resistance syndrome, a risk factor for developing diabetes and heart disease. Another research focus in Gross’s laboratory is the role of gene expression and genetic susceptibility in populations at risk for type-2 diabetes. Despite low rates of obesity, Southeast Asians have high rates of type-2 diabetes, placing a high public health and economic burden upon governments in that part of the world. Gross’s research team is participating in major NIH-funded studies of genetic and environmental factors of people with type-2 diabetes in India and Singapore using genetic sequencing, genotyping, and analysis of biochemical receptors. One of the goals is to identify early onset type-2 diabetes in people ages 10 to 30 in order to initiate treatment and prevent or delay the development of cardiovascular complications. Dr. Gross also participates in a program funded by the NIH’s Fogarty International Center to strengthen India’s clinical research and training capacity. A third area of focus is dietary flavonoids and their biological activities. Dr. Gross is the President of PhenHRIG, a small society devoted to understanding the health effects and activities of flavonoids.

Research

Publications

  • Keyserling TC, Samuel-Hodge CD, Pitts SJ, Garcia BA, Johnston LF, Gizlice Z, Miller CL, Braxton DF, Evenson KR, Smith JC, Davis GB, Quenum EL, Elliott NT,Gross MD, Donahue KE, Halladay JR, Ammerman AS. A community-based lifestyle and weight loss intervention promoting a Mediterranean-style diet pattern evaluated in the stroke belt of North Carolina: the Heart Healthy Lenoir Project. BMC Public Health. 2016 Aug 5;16:732. doi: 10.1186/s12889-016-3370-9.
  • Meyer KA, Benton TZ, Bennett BJ, Jacobs DR Jr, Lloyd-Jones DM, Gross MD, Carr JJ, Gordon-Larsen P, Zeisel SH. Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).
    J Am Heart Assoc. 2016 Oct 21;5(10). pii: e003970.
  • Sharma S, Colangelo LA, Lloyd-Jones D, Jacobs DR Jr, Gross MD, Gidding SS, Greenland P. Longitudinal associations between adiponectin and cardiac structure differ by hypertensive status: Coronary Artery Risk Development in Young Adults. Cardiovasc Endocrinol. 2016 Jun;5(2):57-63.
  • Kan M, Auer PL, Wang GT, Bucasas KL, Hooker S, Rodriguez A, Li B, Ellis J, Adrienne Cupples L, Ida Chen YD, Dupuis J, Fox CS, Gross MD, Smith JD, Heard-Costa N, Meigs JB, Pankow JS, Rotter JI, Siscovick D, Wilson JG, Shendure J, Jackson R, Peters U, Zhong H, Lin D, Hsu L, Franceschini N, Carlson C, Abecasis G, Gabriel S, Bamshad MJ, Altshuler D, Nickerson DA, North KE, Lange LA, Reiner AP; NHLBI-Exome Sequencing Project., Leal SM. Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project. Eur J Hum Genet. 2016 Aug;24(8):1181-7. doi: 10.1038/ejhg.2015.272.
  • Alonso A, Misialek JR, Michos ED, Eckfeldt J, Selvin E, Soliman EZ, Chen LY,Gross MD, Lutsey PL. Serum 25-hydroxyvitamin D and the incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study.
    Europace. 2016 Aug;18(8):1143-9. doi: 10.1093/europace/euv395.
  • Carson AP, Muntner P, Selvin E, Carnethon MR, Li X, Gross MD, Garvey WT, Lewis CE.Do glycemic marker levels vary by race? Differing results from a cross-sectional analysis of individuals with and without diagnosed diabetes.
     BMJ Open Diabetes Res Care. 2016 Jun 10;4(1):e000213. doi: 10.1136/bmjdrc-2016-000213.
  • Odegaard AO, Jacobs DR Jr, Sanchez OA, Goff DC Jr, Reiner AP, Gross MD. Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes. Cardiovasc Diabetol. 2016 Mar 24;15:51. doi: 10.1186/s12933-016-0369-6.
  • Black CN, Penninx BW, Bot M, Odegaard AO, Gross MD, Matthews KA, Jacobs DR Jr. Oxidative stress, anti-oxidants and the cross-sectional and longitudinal association with depressive symptoms: results from the CARDIA study. Transl Psychiatry. 2016 Feb 23;6:e743. doi: 10.1038/tp.2016.5.
  • Buijsse, Brian, David R. Jacobs Jr, Lyn M. Steffen, Daan Kromhout, and Myron D. Gross. "Plasma Ascorbic Acid, A Priori Diet Quality Score, and Incident Hypertension: A Prospective Cohort Study." PloS one 10, no. 12 (2015): e0144920.
  • Odegaard, Andrew O.; Koh, Woonpuay; Yuan, Jianmin; Gross, Myron D.; Pereira, Mark A. Dietary patterns and mortality in a Chinese population. American Journal of Clinical Nutrition 100(3) 877.883. 2014
  • Chen, Zhanghua; Pereira, Mark A.; Seielstad, Mark; Koh, Woonpuay; Tai, E. Shyong; Teo, Yik Ying; Liu, Jianjun; Hsu, Chris; Wang, Renwei; Odegaard, Andrew O.; Thyagarajan, Bharat; Koratkar, Revati; Yuan, Jianmin; Gross, Myron D.; Stram, Daniel O. Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: The Singapore Chinese health study. PLoS ONE 9 (2) 2014.
  • Michos, Erin D.; Carson, Kathryn A.; Schneider, Andrea L C; Lutsey, Pamela L.; Xing, Li; Sharrett, A. Richey; Alonso, Álvaro Alonso; Coker, Laura H.; Gross, Myron D.; Post, Wendy S.; Mosley, Thomas H.; Gottesman, Rebecca F. Vitamin D and subclinical cerebrovascular disease: The atherosclerosis risk in communities brain magnetic resonance imaging study. JAMA Neurology 174 (7) 1144-1157. 2014.
  • Sijtsma, Femke P C; Meyer, Katie A.; Steffen, Lyn M.; Van Horn, Linda; Shikany, James M.; Odegaard, Andrew O.; Gross, Myron D.; Kromhout, Daan; Jacobs,, David R. Diet quality and markers of endothelial function: The CARDIA study. Nutrition, Metabolism and Cardiovascular Diseases 224 (6) 632-638. 2014
  • Troup, Rasa; Hayes, Jennifer H.; Raatz, Susan K.; Thyagarajan, Bharat; Khaliq, Waseem; Jacobs, David R.; Key, Nigel S.; Morawski, Bozena M.; Kaiser, Daniel; Bank, Alan J.; Gross, Myron D. Effect of Black Tea Intake on Blood Cholesterol Concentrations in Individuals with Mild Hypercholesterolemia: A Diet-Controlled Randomized Trial 115(2) 264-271.e.2. 2014
  • Yang, Baiyu; Thyagarajan, Bharat; Gross, Myron D.; Goodman, Michael; Sun, Yan; Bostick, Roberd Maner. Genetic variants at chromosome 8q24, colorectal epithelial cell proliferation, and risk for incident, sporadic colorectal adenomas. Molecular Carcinogenesis 53 (S1) E187-E192. 2014
  • Simon JA, Murtaugh MA, Gross MD, Loria CM, Hilner JE, Jacobs DR. Relation of ascorbic acid to coronary artery calcification: the Coronary Artery Disease in young Adults (CARDIA) Study. Am J Epidemiol 2004;159:581-8.
    Lee D-H, Gross MD, Jacobs DR. The association of serum carotenoids and tocopherols with g-glutamyltransferase; The CARDIA Study. Clin Chem 2004;50:582-88
  • Kris-Etherton PM, Lefevre M, Beecher GR, Gross MD, Keen CL, Etherton TD. Bioactive Compounds in Nutrition and Health-Research Methodologies for Establishing Biological Function: The Antioxidant and Anti-Inflammatory Effects of Flavonoids on Atherosclerosis. Annu Rev Nutr 2004; 24: 511-538.
  • Gross MD. Flavonoids and Cardiovascular Disease. Pharmaceutical Biology. 2004; Vol 42. Supplement pp 21-35.
    Steffes MW, Gross MD, Schreiner PJ, Yu X, Hilner JE, Gingerich R, Jacobs DR, Jr. Serum adiponectin in young adults--interactions with central adiposity, circulating levels of glucose, and insulin resistance: the CARDIA study. Ann Epidemiol 2004;14:492-8.
  • Thyagarajan B, Brott M, Mink P, Folsom AR, Anderson KE, Oetting WS, Gross M. CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study. Cancer Lett2004;207:183-9.
  • Simon JA, Murtaugh MA, Gross MD, Loria CM, Hulley SB, Jacobs DR, Jr. Relation of ascorbic acid to coronary artery calcium: the Coronary Artery Risk Development in Young Adults Study. Am J Epidemiol 2004;159:581-8.
  • Lee DH, Gross MD, Jacobs DR, Jr. Association of serum carotenoids and tocopherols with gamma-glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) Study. Clin Chem 2004;50:582-8.
  • Wilson DM, Wang Y, Cullen K, Baranowski T, Himes JH, Gross M, McClanahan B, Robinson T. Assessing Weight-related Biochemical Cardiovascular Risk Factors in African American Girls. Obesity Research
    Guettier JM, Georgopoulos A, Tsai MY, Radha V, Shanthirani S, Deepa R, et al. Polymorphisms in the Fatty Acid-Binding Protein 2 and Apolipoprotein C-III Genes Are Associated with the Metabolic Syndrome and Dyslipidemia in a South Indian Population. J Clin Endocrinol Metab 2005;90:1705-11.
  • Gross M, Steffes M, Jacobs DR, Jr., Yu X, Lewis L, Lewis CE, Loria CM. Plasma F2-isoprostanes and coronary artery calcification: the CARDIA Study. Clin Chem 2005;51:125-31.
  • Iribarren C, Gross MD, Darbinian JA, Jacobs DR, Jr., Sidney S, Loria CM. Association of lipoprotein-associated phospholipase A2 mass and activity with calcified coronary plaque in young adults: the CARDIA study. Arterioscler Thromb Vasc Biol 2005;25:216-21.