Stephen Jameson, PhD

Professor, Department of Laboratory Medicine and Pathology

Stephen Jameson

Contact Info

james024@umn.edu

Office Phone 612-625-1496

Fax 612-625-2199

Lab Phone 612-625-1626

Mailing Address:
WMBB
2641D
2101 6th St. SE
Minneapolis, MN 55455

Scripps Clinic and Research Foundation, CA (Immunology), 1990

University of Washington (Immunology), 1995

PhD, Cambridge University, England (Immunology), 1988

BSci, Bristol University, England (Cellular Pathology), 1984

Summary

Dr. Jameson studies the factors that regulate the survival and activation of mature T-cells in the peripheral lymphoid system that engage in immune responses. An area of his current research interest is learning how vaccines work in the T-cell context. In experimental studies in mice, he and his colleagues applied vaccines to skin to see whether epicutaneous application was sufficient to generate an effective memory CD8 T-cell response that would be protective against bacterial and viral infection. Though somewhat less protective than injected or oral vaccine, epicutaneous immunization using adhesive bandages could potentially be used in developing countries due to the ease of application.

Awards & Recognition

  • University of Minnesota, Academy of Excellence in Health Research 2014
  • Frederick W. Alt Award for New Discoveries in Immunology, Cancer Research Institute, 2011
  • Special Fellowship, The Leukemia Society of America, 1993 - 1996
  • Postdoctoral Fellowship, Cancer Research Institute, 1989 - 1991

Professional Associations

University of Minnesota Cancer Center, 1996 - present

Research

Research Summary/Interests

The T-cell component of the adaptive immune system is proving to be highly complex, with many T-cell subcategories being identified as investigative tools such as flow cytometry and transgenic technologies become more sophisticated. Flow cytometry, for example, now allows researchers to identify and isolate T-cells with tens or even hundreds of characteristics compared to just a handful two decades ago. These technological advances have enabled Jameson’s team to identify subsets of memory T-cells with different functions including those most protective against disease. One subset of memory T-cells in the circulation appears early in the immune response but these cells tend to die off (short-lived effector cells); Jameson’s group characterized a related subset that survive for much longer (long-lived effector cells). These memory T-cells, which were thought to be relatively unimportant in immune response, turn out to be the best among memory T-cell populations for protecting against viral and bacterial infections in experimental animals. Jameson’s team is exploring why these long-lived effector cells possess a functional advantage over other memory T-cells.

In a companion line of inquiry, Jameson and his colleagues have identified another subset of memory T-cells produced by an immune response that take up residence in organs and tissues such as the lung, liver, and skin and not in the circulatory system. Recently, they have found that a transcription factor called Kruppel-like factor 2 (KLF-2) acts as a kind of toggle switch in these cells that allows them to migrate out of body tissues when the switch is turned on and keeps them in place when the switch is turned off. These “resident” memory T-cells provide a valuable protective function because many infections are localized to barrier and mucosal surfaces where these cells reside, monitor threats, and recruit additional support if necessary.

Identifying the molecular signals that guide the development and behavior of long-term effector T-cells and resident memory T-cells will guide future research in Jameson’s laboratory. A comprehensive understanding of localized memory T-cells is key to developing novel immunization strategies including vaccines that produce a robust immune response in older people.

Publications

  • Lee YJ, Starrett GJ, Lee ST, Yang R, Henzler CM, Jameson SC, Hogquist KA. Lineage-Specific Effector Signatures of Invariant NKT Cells Are Shared amongst ?? T, Innate Lymphoid, and Th Cells. J Immunol. 2016 Aug 15;197(4):1460-70. doi: 10.4049/jimmunol.1600643. Epub 2016 Jul 6.
  • Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA. Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response. Immunity. 2015 Sep 15;43(3):566-78.
  • Xing Y, Wang X, Jameson SC, Hogquist KA. Late stages of T cell maturation in the thymus involve NF-?B and tonic type I interferon signaling. Nat Immunol. 2016 May;17(5):565-73. doi: 10.1038/ni.3419. Epub 2016 Apr 4.
  • Fraser, K.A., Rosato, P.C., Filali-Mouhim, A., Sekaly, R.P., Jenkins, M.K., Vezys, V., Haining, W.N., Jameson, S.C., and D. Masopust. (2016). Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 532:512-516
  • Fulton, R.B.,Y. Xing, J.A. Best, A.W. Goldrath, K.A. Hogquist and S.C. Jameson. (2014) TCR sensitivity to self-peptide-MHC dictates naïve CD8 T-cells’ capacity to respond to foreign antigens. Nat.Imm. 16:107-117
  • Lee, J.-Y., C.N. Skon, Y.J. Lee, S. Oh, J.J. Taylor, D. Malhotra, M.K. Jenkins, M.G. Rosenfeld, K.A. Hogquist and S.C. Jameson. (2014) The transcription factor KLF2 restrains CD4+ T follicular helper cell differentiation. Immunity 42:252-264
  • Jameson SC, and Renkema, KR. (2014) An Uncommon Tail about the Common ?-Chain. Immunity 40 (6):  859–860
  • Skon, C.N., J.Y. Lee, K.G. Anderson, D. Masopust, K.A. Hogquist, and S.C. Jameson. (2013) Transcriptional downregulation of S1PR1 is required for establishment of resident memory CD8+ T-cells. Nature Immunology. 14:1285-1293
  • Lee YJ, Holzapfel KL, Zhu J, Jameson SC, and KA Hogquist. (2013) Steady state production of IL-4 modulates immunity in different strains and is determined by lineage diversity of iNKT cells. Nature Immunology 14:114.