Timothy Moss

Molecular Genetics Fellow, Department of Laboratory Medicine and Pathology

Timothy Moss

Contact Info

MD, MD, University of Iowa School of Medicine

Residency in Clinical Genetics, Baylor College of Medicine

Summary

Research

Publications

Norwood, L.E.*, Moss, T.J.*, Cook, S.L., Wright, L., Hendrix, M.J.C., Kirschmann, D., Wallrath, L.L. A requirement for dimerization of HP1Hsalpha in suppression of breast cancer invasion. J Biol Chem. 2006 Jul 7; 281(27):18668-76.

Moss, T.J., Wallrath, L.L. Connections between epigenetic gene silencing and human disease. Mutation Research. 2007 May 1; 618(1-2):163-174.

Spiro JE, Beaudet AL, Brewton CM, Chu Z, Dempsey AG, Evans YL, Garza S, Hunter JV, Kanne SM, Laakman AL, Lasala MW, Llorens AV, Marzano G, Moss TJ, Nowell KP, Proud MB, Ramocki MB, Chen Q, Vaughan R, Berman J, Blaskey L, Hines K, Kessler S, Khan SY, Qasmieh S, Bibb AL, Paal AM, Page PZ, Smith-Packard B, Buckner R, Burko J, Lian Cavanagh A, Cerban B, Snow AV, Grant PE, Green Snyder L, McNally Keehn R, Miller DT, Miller FK, Endre Olson J, Spence SJ, Triantafallou C, Visyak N, Atwell C, Benedetti M, Fischbach GD, Greenup M, Packer A, Tjernagel J, Bukshpun P, Cheong M, Dale C, Gobuty SE, Hinkley L, Jeremy RJ, Lee H, Luks TL, Marco EJ, Martin AJ, McGovern KE, Mukherjee P, Nagarajan SS, Owen J, Paul BM, Pojman NJ, Sinha T, Swarnakar V, Wakahiro M, Alupay H, Aaronson B, Ackerman S, Ankenmann K, Aylward E, Elgin J, Gerdts J, Johnson K, Reilly B, Shaw D, Steinman K, Stevens A, Ward T, Wenegrat J, Roberts TP, Ledbetter DH, Lese Martin C, Goin-Kochel RP, Bernier R, Faucett WA, Sherr EH, Hanson E, Chung WK. Simons Variation in Individuals Project (Simons VIP): a genetics-first approach to studying autism spectrum and related neurodevelopmental disorders. Neuron. 2012 March 22; 73(6):1063-7.

Celestino-Soper, P.B.S; Violante, S.; Crawford, E.L.; Luo, R.; Sadikovic, B.; Lee, K.; Lo, C.; Gao, K.; Person, R.E.; Moss, T.J.; German, J.R.; Huang, N.; Shaw, C.A.; Sanders, S.J.; Geschwind, D.; Sutcliffe, J.S.; Hurles, M.E,; Wanders, R.J.A.; Leal, S.M.; Cook, E.H,; Goin-Kochel, R.P.; Vaz, F.M.; Arthur L. Beaudet. A Common X-linked Inborn Error of Carnitine Biosynthesis Is a Risk Factor for Non-dysmorphic Autism. PNAS, 2012 May 22; 109(21):7974-81.

Zufferey F, Sherr EH, Beckmann ND, Hanson E, Maillard AM, Hippolyte L, Macé A, Ferrari C, Kutalik Z, Andrieux J, Aylward E, Barker M, Bernier R, Bouquillon S, Conus P, Delobel B, Faucett WA, Goin-Kochel RP, Grant E, Harewood L, Hunter JV, Lebon S, Ledbetter DH, Martin CL, Männik K, Martinet D, Mukherjee P, Ramocki MB, Spence SJ, Steinman KJ, Tjernagel J, Spiro JE, Reymond A, Beckmann JS, Chung WK, Jacquemont S; Simons VIP Consortium; 16p11.2 European Consortium. A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders. J Med Genet. 2012 Oct; 49(10):660-8.

Burrage L.C., Lu J.T., Liu D.S., Moss T.J., Gibbs R., Schlesinger A.E., Bacino C.A., Campeau P.M., Lee B.H. Early Childhood Presentation of Czech Dysplasia. Clin Dysmorphol. 2013 Apr;22(2):76-80.

Wangler, M.F., Gonzaga-Jauregui, C., Gambin, T., Penney, S., Moss, T.J., Chopra, A., Probst, F.J., Xia, F., Yang, Y., Werlin, S., Eglite, I., Kornejeva, L., Bacino, C.A., Baldridge, J., Neul, J., Lehman, E.L., Larson, A., Beuten, J., Muzny, D.M., Jhangiani, S., Baylor-Hopkins Center for Mendelian Genomics, Gibbs, R.A., James R. Lupski, J.R., Beaudet, A. Heterozygous De Novo and Inherited Mutations in the Smooth Muscle Actin (ACTG2) Gene Underlie Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome. PLoS Gene. 2014 Mar 27;10(3):e1004258.

Granadillo, J.L.., Moss, T.J., Lewis, R.A., Austin, E.G., Kefler, H., Wang, J., Wong, L.J., Scaglia, F. Early Onset and Severe Clinical Course Associated with the m.5540G>A Mutation in MT-TW. Mol Genet Metab Rep. 2014 1:61-65.

Wagnon, J., Barker, B., Hounshell, J., Haaxma, C., Shealy, A., Moss, T., Parikh, S., Messer, R., Patel, M., Meisler, M. Pathogenic Mechanisms of Recurrent Mutations of SCN8A in Epileptic Encephalopathy. Annals of Clinical and Translational Neurology. 2015. 3(2):114-23.

Tanaka A.J., Bai R., Cho MT, Anyane-Yeboa K., Ahimaz P., Wilson A.L., Kendall F., Hay B., Moss T., Nardini, M., Bauer M., Retterer K., Juusola J., Chung W.k. De Novo Mutations in PURA are associated with hypotonia and developmental delay. Cold Spring Harb. Mol. Case Stud. 2015

Chen CA, Bosch DG, Cho MT, Rosenfeld JA, Shinawi M, Lewis RA, Mann J, Jayakar P, Payne K, Walsh L, Moss T, Schreiber A, Schoonveld C, Monaghan KG, Elmslie F, Douglas G, Boonstra FN, Millan F, Cremers FP, McKnight D, Richard G, Juusola J, Kendall F, Ramsey K, Anyane-Yeboa K, Malkin E, Chung WK, Niyazov D, Pascual JM, Walkiewicz M, Veluchamy V, Li C, Hisama FM, de Vries BB, Schaaf C. The Expanding Clinical Phenotype of Bosch-Boonstra-Schaaf Optic Atrophy Syndrome: 20 new cases and possible genotype-phenotype correlation. Genetics in Medicine. 2016 Nov;18(11):1143-1150

D’Angelo D. et al. Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior and Medical Comorbidities. JAMA Psychiatry. 2016. 73(1):20-30.

Hicks, J.K., Stowe D., Willner M.A., Wai M., Daly T., Gordon S.M., Lashner B.A., Parikh S., White R., Teng K., Moss T., Erwin A., Chalmers J., Eng, C., Knoer S. Implementation of Clinical Pharmacogenomics within a Large Health SystemL From Electronic Health Record Decision Support to Consultation Services. Pharmacotherapy. 2016

Hicks, J.K., Shealy A, Schreiber A., Coleridge M., Noss R., Nardini M., Natowicz M., Moran R., Moss, T., Zurcher V., Erwin A., Eng, C. Patient Decisions to Receive Incidental Pharmacogenomic Findings from Clinical Exome Sequencing. Submitted

Book Chapters

Moss, T.J., Allfrey, V.G., Wallrath, L.L. Nucleoproteins. McGraw Hill Encyclopedia of Science & Technology, 10th Ed. April, 2007.

Moss, T.J., Wallrath, L.L. Diverse roles of HP1Hsa in chromatin dynamics, transcriptional regulation and breast cancer metastasis. New Developments in Metastasis Suppressor Research. (ed. Paul Jackson). Nova Science Pub Inc. April, 2007. 123-150.

Clinical

Specialties

  • Clinical Genetics