Molecular Pathology & Genomics

 

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Vision

To be a world class division of LMP that provides department, collegiate and national leadership in the pursuit of excellence in molecular pathology and genomic research, education and clinical service

Strategic Intent

To foster a culture of innovation and academic excellence by promoting synergistic collaborations among members of the Division of Molecular Pathology and Genomics

Leadership

 

Molecular Pathology and Genomics Membership 

Search our Research Network


Fellowships
Laboratory Genetics & Genomics Fellowship
Molecular Genetic Pathology Fellowship


Grand Rounds sponsored by the Division of Molecular Pathology and Genomics

 
April 11, 2018
Chad Cowan, PhD
Harvard Cell Institute 
Harvard Medical School
Boston, Massachusetts 

"Investigating metabolic disease with human pluripotent stem cells"

    • Understand the current use of human pluripotent stem cells for modeling metabolic disease;
    • Apply modern gene editing techniques to understand the genetic causes of metabolic diseases
    • Develop a strategy to identify novel therapeutics for metabolic disease
 
May 16, 2018

Lynn Bry, MD, PhD
Associate Pathologist, Brigham and Women’s Hospital
Associate Professor of Pathology
Harvard Medical School 
Boston, Massachusetts


LMP Research Forum


 External Links

U of M Genomics Center

NovaSeq

U of M Genomics Center ramps up for cancer diagnostics

The University of Minnesota Genomics Center (UMGC) is a core research services facility and a key resource for LMP's Division of Molecular Pathology and Genomics. With funding from MHealth, UMGC just added an Illumina NovaSeq to its armamentarium of high-performance DNA sequencers and related molecular analytic and processing instruments.  The NovaSeq machine promises the throughput, speed, and flexibility to complete genomic analysis faster and more economically than ever before.  That will be essential for the field of clinical diagnostics to advance, in the view of Kenny Beckman, UMGC director.

UMGC partners with the Molecular Diagnostic Laboratory for which it provides rapid turnaround next-generation sequencing (NGS) of patient DNA.  It is also a key player in LMP’s partnership with MHealth in clinical genomics.  Beckman said NGS can help clarify tumor subtypes, track tumor progression, reveal a patient’s likely response to chemotherapeutic agents, and potentially serve as a prognostic indicator.  “There might be a small fraction of highly aggressive cells that might not show up in a bulk analysis,” he said.  You could kill off 90 percent of [tumor] cells but if there are some cells that are resistant to chemotherapy, that’s not going to buy you time.”  UMGC is at the forefront of advancing single-cell sequencing, a cutting-edge technology that can shed light on nature of cellular heterogeneity in cancer and other diseases.  

Beckman sees no reason why there can’t be another twenty years of improvement in sequencing technology.  Yet the amount of data generated through increasingly powerful sequencing instruments presents bioinformatics challenges at the level of hardware, software, interpretation, “and, maybe the thorniest, in visualization and reporting.  You either have to make something a human can see, or you need to have artificial intelligence to convert it into some kind of [clinical] recommendation.”

In Beckman’s view, whole genome sequencing infrastructure costs will eventually result in private companies doing the bulk of routine sequencing for clinical genomics.  University-based facilities like UMGC will focus on working with molecular pathologists to develop algorithms that identify and characterize disease subtypes.

University of Minnesota Genomics Center (UMGC)

News

Save the date!  

The annual MPG Symposium will be held October 11, 2018 at Coffman Memorial Union with keynote speaker Dr. Muneesh Tewari from the University of Michigan.   He will discuss the integration of cell free DNA with wearable sensors for early cancer diagnosis.  

Tewari is Ray and Ruth Anderson-Laurence Sprague Memorial Research Professor, Professor of Internal Medicine, and Professor of Biomedical Engineering.  He is also affiliated with the Department of Computational Medicine and Bioinformatics.

Tewari Laboratory at the University of Michigan

 

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Recent MPG Faculty Publications

Yang R, Van Etten JL, Dehm SM.  Indel detection from DNA and RNA sequencing data with transIndel. BMC Genomics. 2018 Apr 19;19(1):270. doi: 10.1186/s12864-018-4671-4.

Rashidi A, Nelson AC, Linden MA, Weisdorf DJ, Dolan MM, Ustun C. Genomics of clonal evolution in a case of essential thrombocythemia.  Leuk Lymphoma. 2018 Feb;59(2):497-500. doi: 10.1080/10428194.2017.1337113. Epub 2017 Jun 11.

Pérez Ortiz JM, Orr HT. Spinocerebellar Ataxia Type 1: Molecular Mechanisms of Neurodegeneration and Preclinical Studies. Adv Exp Med Biol. 2018;1049:135-145. doi: 10.1007/978-3-319-71779-1_6.

Lou E, D'Souza D, Nelson AC. Therapeutic Response of Metastatic Colorectal Cancer Harboring a KRAS Missense Mutation After Combination Chemotherapy With the EGFR Inhibitor Panitumumab.J Natl Compr Canc Netw. 2017 Apr;15(4):427-432. PMID:28404754