The Mono Project : EBV Diseases Research Program

The Mono Project 

Our research is dedicated to learning how Epstein-Barr virus (EBV) causes disease and developing a vaccine against it. 

Mono is an infectious disease caused by EBV, a member of the herpesvirus family. EBV is one of the oldest and most common human viruses, infecting roughly 90% of adults worldwide. To cause mono, EBV spreads most commonly through the exchange of oral fluids. For this reason, mono has been thought of as "the kissing disease," which we recently have proven to be true. 

Besides causing mono, EBV is also a causative agent of several forms of cancer, including Burkitt’s lymphoma, Hodgkin’s lymphoma, and nasopharyngeal carcinoma. Additionally, new evidence is supporting the link that EBV plays a role in the pathogenesis of multiple sclerosis. EBV is also a risk factor for PTLD in solid organ and hematopoietic cell (bone marrow) transplant patients.

Epstein-Barr Virus Vaccine

Researchers at the Mono Project are currently partnering with industry to develop a vaccine that could potentially prevent EBV-caused diseases, such as infectious mono, EBV-associated diseases, and MS. A vaccine could also potentially prevent severe illness or even death from EBV infection following transplantation, especially in pediatric patients who have not been exposed to the virus and have no immunity to it. Stay tuned for more updates! To be the first to recieve information on the vaccine progress please subscribe to our email list: 

Chronic Mono

Chronic mono follows an EBV infection with two patterns, including continuous illness for weeks, months or years after onset or recovery from the acute illness but lingering or recurring symptoms for years. For more information on chronic mono click here to download current literature to read and share with your healthcare provider.

KARE 11 News Story

U of M Researchers Developing a Vaccine to Prevent Mono, MS

Updated: 1/30/2018

Impact of EBV

280,000 cases of mono in U.S college freshmen annually

200,000 new cases of EBV-associated cancers annually worldwide

2.3 million cases of multiple sclerosis worldwide

Donate to The Mono Project

Contact Information

Phillips-Wangensteen Building

15-119 Phillips-Wangensteen Building
420 Delaware St. SE
Minneapolis, MN 55455 

Office: 612-625-3998