The Department of Laboratory Medicine and Pathology at the University of Minnesota Medical School is committed to bringing leading-edge basic and applied research and innovation to patient care.
The research-intensive faculty within the department have several major focus areas including cancer, immunology, cardiovascular disease, renal disease, diabetes, and genetics. The faculty consist of tenured associate and full professors, several of which currently hold endowed chairs or professorships. They interface with University of Minnesota departments and centers such as the Center for Immunology, Masonic Cancer Center, and the Institute for Translational Neuroscience.
Downtown Minneapolis viewed from a basic research laboratory
Brenner tumor (IHC for E-cadherin)
Polychromatic crystalline keratopathy of the cornea
Pap smear with endocervical adenocarcinoma in situ
Macrophages (in red) surrounding a growing ductal structure in the mammary gland
Human melanoma cells in culture
A human melanoma cell. The arrows point to cell-surface receptors used for metastasis. These receptors are targets for drug therapy.
Bone marrow touch imprint, Wright-Giemsa stained, from a patient with smoldering plasma cell myeloma
Mouse brain neurons (red) and associated tau neurofibrillary tangles (green). Tau tangles are implicated in Alzheimer's disease.
Noteworthy LMP faculty publications
As we approach the end of the academic year, we wanted to highlight some particularly noteworthy publications by our faculty:
Li D, Radulescu A, Shrestha RT, Root M, Karger AB, Killeen AA, Hodges JS, Shu-ling F, Ferguson A, Garg U, Sogoll LJ, Burmeister LA. Association of biotin ingestion with the performance of hormone and nonhormone assays in health adults. Journal of the American Medical Association 2017; Sept 26, 318(12), 1150-1160. H Index: 582, SJR (journal impact): 6.87
Folsom AR, Roetker NS, Kelley ST, Tang W, Pankratz N. Failure to replicate thrombomodulin genetic variant predictors of venous thromboemolism in African Americans. Blood 2017; 130(5): 688-690. H Index: 394, SJR (journal impact): 5.84
Van Etten J, Nyquist M, Li Y, Yang R, Ho Y, Johnson R, Ondigi O, Voytas DF, Henzler C, Dehm SM. Targeting a single alternative polyadenylation site to coordinately block expression of androgen receptor mRNA splice variants in prostate cancer. Cancer Res. 2017; 77(19): 5228-5235, 2017. H Index: 390, SJR (journal impact): 4.75
Paulson HL, Shakkottai VG, Clark HB, and Orr HT. Polyglutamine spinocerebellar ataxias - from gene identification to potential treatments, Nature Revs. Neuroscience 2017; 18:613-626. H Index 337, SJR (journal impact): 19.02
Katerndahl, CDS, Heltemes-Harris LM, Willette MJL, Henzler C.M, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Muschen M, Kornbau SM, and Farrar MA. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival. Nat Immunol., 2017; 18: 694-704. H Index 323, SJR (journal impact): 14.47
The Nature of Disease: Pathology for Allied Health Students
LAMP 4177 (3 credits, Summer 2018)
The online course for undergraduate students is a study of the mechanisms of human disease. Students receive a substantial foundation in the pathobiology of human disease and medical terminology. The course covers general pathology followed by organ system pathology.
Summer registration for LAMP 4177 spring semester starts March 8th.
LAMP 4177 is a good foundation course for a degree in the Health Sciences including:
- Medical Laboratory Science
- Health & Wellness ICP
- Spring semester online
- Summer semester online
- Grading: A/F or S/N
Non University of Minnesota students are welcome and can register through the College of Continuing and Professional Studies (CCAPS), University of Minnesota.
Flanagan focuses on aging and dementia
LMP neuropathologist Maggie Flanagan specializes in investigating neurodegenerative diseases associated with aging. She is the department’s lead investigator for the Nun Study of Aging and Alzheimer's disease, a longitudinal study of Catholic nuns who donated their brains to research.
The study was launched in 1986 to determine the causes and prevention of Alzheimer’s disease, other brain diseases, and mental and physical disability associated with old age. Nearly 700 School Sisters of Notre Dame have participated.
Flanagan and Laura Hemmy, Department of Psychiatry, spoke about the Nun study in a recent LMP Research Forum. Since the study was initiated investigators have found:
- Variability in correspondence between clinical state and brain pathology
- A single copy of the APO e4 genetic allele is associated with a higher risk of dementia
- Alzheimer’s disease together with vascular brain lesions have a compounding effect
- High levels of linguistic ability earlier in life may protect against cognitive decline in old age
Flanagan said the Nun study is “fundamental to our knowledge of brain aging” in part because about 90 percent of study participants consent to brain autopsy following their death, making possible both anatomical and molecular studies of brain tissue. She said she is “extremely grateful for the ongoing contributions of the sisters. I am just so lucky to have the opportunity to work with such an amazing and scientifically critical cohort of women.”
Flanagan and Hemmy are featured in Dr. Sanjay Gupta’s CNN story on aging and Alzheimer’s disease involving the Nun study. The story has been shown in Europe and will air in March in the US. Flanagan appears at the 2:04 mark of the link below.